The studies were conducted with an object to develop stable, safe and efficient, delivery system for aceclofenac. During the course of studies different organogel formulations of aceclofenac for topical application were developed by using lecithin soya, isopropyl myristate, pluronic F-127, purified water, sorbic acid, potassium sorbate, vitamin E, methyl salicylate and menthol. The formulated organogels were evaluated for psychorheological characteristic, drug content, pH, spreadability. The viscosities of different formulations were determined by using Brookfield Viscometer at 25°C, the viscosity of formulations increases with increase in concentration of organogelator. The developed formulations then subjected to in vitro diffusion study. The two formulations showed best release having flux > 0.18 mg/cm2/h were selected and modified with incorporation of 10% methyl salicylate and 5% menthol. Further efficacy of these formulations was evaluated and compared with conventionally used marketed standard formulation by anti-inflammatory activity on albino rats using carageenan induced rat paw edema model, within short period promising edema inhibition was observed. Safety was determined through skin irritancy testing on Guinea pigs for seven days showing no signs of skin irritation. Finally stability studies were carried out for three months doesn’t showed any signs of separation within gel indicating overall stability. The result indicates that pluronic lecithin organogels (PLOs) serves as an excellent vehicle for topical delivery of aceclofenac.
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